Are you asking hypothetically? Or actually?
Real astronauts use treadmills and other exercise equipment to maintain their strength—although it’s imperfect and they do often lose muscle mass while in space.
Hypothetically, like if living on a space station, humans could create a kind of artificial gravity by using centrifugal force. Imagine a ring or donut-shaped space station that is spinning with humans inside. The force of the spin would push humans “down” towards the inside edge of the station, simulating gravity.
I’m not sure what you mean by “run in space.” Do you mean inside a spacecraft in microgravity? Astronauts on the ISS use a [special treadmill](https://www.youtube.com/watch?v=8scFoH36EmY) that holds has a harness that holds them down using bungee cords so the can run. Theoretically humans could also run on a rotating spacecrat that uses the centrifugal force to simulate gravity.
Maintaining muscle mass is also all about exercise. Astronauts exercise for several hours a day on the treadmill and a resistive exercise device to keep their muscles working. Even that doesn’t maintain muscle mass so much as it reduces the rate at which muscle atrophy occurs. Again, a plausible solution to this would be a rotating spacecraft that simulates gravity.
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