Are you asking hypothetically? Or actually?
Real astronauts use treadmills and other exercise equipment to maintain their strength—although it’s imperfect and they do often lose muscle mass while in space.
Hypothetically, like if living on a space station, humans could create a kind of artificial gravity by using centrifugal force. Imagine a ring or donut-shaped space station that is spinning with humans inside. The force of the spin would push humans “down” towards the inside edge of the station, simulating gravity.
Latest Answers