I’m not sure what you mean by “run in space.” Do you mean inside a spacecraft in microgravity? Astronauts on the ISS use a [special treadmill](https://www.youtube.com/watch?v=8scFoH36EmY) that holds has a harness that holds them down using bungee cords so the can run. Theoretically humans could also run on a rotating spacecrat that uses the centrifugal force to simulate gravity.
Maintaining muscle mass is also all about exercise. Astronauts exercise for several hours a day on the treadmill and a resistive exercise device to keep their muscles working. Even that doesn’t maintain muscle mass so much as it reduces the rate at which muscle atrophy occurs. Again, a plausible solution to this would be a rotating spacecraft that simulates gravity.
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