How did certain anxiety disorders (like germophobia) present before the acceptance of germ theory?

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Did they used to be focused on things like the humors and stuff like that? Was hypochondria/germophobia not really a thing before germ theory? Are there any other disorders that have changed/presented differently due to new widespread knowledge about the world?

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King Charles the 4th of France (1368–1422) is a famous example of someone who believed he was made of glass, a condition known as glass delusion. To protect himself from breaking, he would wear clothing reinforced with iron rods and stay wrapped in blankets for hours.

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