For the prey, its life and death when attacked so they tend to fight back with everything they have got. For the predator, its just one meal! A serious injury just to get one meal (unless they are absolutely desperate) is a big big deal, it could prevent them from hunting for a long while. Thus, predators tend to go for easy prey. If driven to it by near starvation they will attack large prey but otherwise they wont risk it because like others have already answered, the large slow animals can pack a mighty punch.
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