It’s all in the brain, except for the dilation of the pupils that makes everything brighter on many hallucinogens.
LSD binds to serotonin receptors, in a way it causes neurons to misfire, leading to spurious signals.
Dissociatives, such as ketamine, instead diminish the signals coming to your brain. Your brain reacts by increasing gain, which makes more noise get through – similarly to what you get when you have a very quiet recording and you increase volume to very high levels.
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