In addition to isolating frequencies and stereo, there are also a few other ways.
1: Isolate and chop different parts of a beat to isolate each instrument, you can pitch up or down if you only get one note.
2: If you need an acapella, and have the original track and the instrumental, you can sometimes isolate the accapella by combining the original with a version of the instrumental with the waveforms inversed to cancel each other out
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