How does buprenorphine and naloxone interact with each other in Suboxone? I’ve heard that buprenorphine is more potent than morphine, how does the naloxone prevent this?
In: Biology
Naloxone is not well absorbed orally while buprenorphine is. At high enough dosage, the effect of naloxone (which blocks opioid effects) does start to become significant, which decreases the effect from dose escalation. The biggest reason is for injection though, as naloxone is fully active there, and injecting will not give you a significant high, and might even precipitate withdrawal.
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