It depends what you’re talking about. Taking pain as an example, there is emerging evidence that we make our own painkillers in our body naturally if we believe we’re taking a painkiller medication, and this tells specific parts of our brain and body that we are not in pain.
Source: [https://pubmed.ncbi.nlm.nih.gov/16120776/](https://pubmed.ncbi.nlm.nih.gov/16120776/) (this is all fancy medical wording for “when people took placebo, very specific parts of areas of the brain/body are activated by our own, naturally-made chemicals” with an understanding that these are the same very specific parts that opioids act on)
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