Always wondered this I see posters in my school about it too
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Chemicals like those found in certain markers, glues, paints, and other solvents contain chemicals that readily turn into gases when exposed to air, and when you breathe them in, the gasses readily absorb into your bloodstream and get carried to your brain. Once in your brain, they act in one of two ways – either they simply displace oxygen (so the high you feel is actually from lack of oxygen), or they mimic, interfere with, or alter the effects of certain chemicals in your brain called neurotransmitters that are responsible for brain cells sending signals to each other.
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