While most of the responses itt are accurate as far as our current medical understanding is concerned, [biochemists are making a lot of progress in understanding the signaling pathways that regulate lipolysis,](https://www.sciencedirect.com/science/article/pii/S0898656805002299?casa_token=ZqRp4CXYg60AAAAA:2R9YWODZL8kRdRokKCLsaO4PxojQBIeiANKMVaVXp05pcLOOcmDDw9HDtEidaeFrGc1IxMYnf3bV) and several proteins have been identified that are associated with fat burning. [There was an investigational peptide that appeared in a paper a few years ago](https://en.wikipedia.org/wiki/Prohibitin-targeting_peptide_1) but very little follow-up was done and the project was abandoned. You can find fraudulent knockoffs of the drug on sketchy dieting aid sites.
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