How is it the ISS can travel at 17,400 MPH, but astronauts seem unaffected at all?

Question

EDIT: Thank you all for your kind yet informative responses!

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Answer 1

Once you reach a certain speed and acceleration drops to 0 then for the person inside the system (ISS) nothing will seem to have any effect. Only a person outside the system will appreciate the 17.400 MPH.
It is like you are on a train.
Those high speed can reach 200-300(?) Kph, but as long as you go on a straight line without any change in altitude, or bumps, you feel like you do not move.