How/Why does benadryl work for dystonic reactions?

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So. im studying for a neurology test, and ive got a question in my head i cant seem to find the answer to.
the only answer i can find is the *indications* *to* **GIVE** *benadryl* when a pt in the feild has a dystonic reaction, or ataxia secondary to SSRI/tricyclic antidepressants/Anti psychotic reactions.

*i know benadryl acts as an inverse agonist at the H1 receptor(cellular migration, nociception, vasodilatation, and bronchoconstriction), reversing effects of histamine on capillaries, reducing allergic reaction symptoms(ie:uticaria).
* benadryl acts as an intracellular sodium channel blocker, resulting in local anesthetic properties.

but me no get why magic pink pill fix jumpy muscles?

In: Biology

2 Answers

Anonymous 0 Comments

First generation H1 antagonists are also anticholinergics. Typical antipsychotics block central dopamine receptors which causes a rise in cholinergic output – the cause of the dystonic reaction. So how do you treat this: with a medication with anticholinergic properties such as benztropine or diphenhydramine because they block central muscarinic receptors.

Anonymous 0 Comments

Whoa! Dystonia outside the little dystonia subreddit with <800 members?! That is unheard of.

I learned what dystonia was at 35, when I got cervical dystonia.