I usually take 1 to see if it causes a placebo effect. If the pain/headache goes away in less than 30 minutes it is probably not from the pill. If I still have a headache but not as bad I will take one more in 30 minutes. Then do the 2 in 4 hours if needed. But with tylenol right now because I cant take aspirin or ibuprofen for a few months.
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