Ibuprofen – why is it recommended to take 2 x tablets every 4 hours but not allowed 1 x tablet every 2 hours. Surely it would make the pain relief longer lasting?
In: Biology
Some of it is about the absorbance rates to the drug into your blood stream when compared against the ‘effective dose’ (while also not producing harmful side effects) needed to actually trigger the receptor responses. Now couple all that craziness with your liver turning it into a form that your kidneys can flush out. (This is probably the simplest way one can talk about pharmacokinetics).
So you have to take enough to take effect, while it’s fighting a constant ‘draining’ effect of it getting removed from your body due to liver/kidneys. If you take less than the lowest does it might have a reduced effect. So you might reduce your benefit meanwhile still putting pressure on your liver/kidneys.
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