A paperclip is a wire that has been bent in a particular way. Unbend one, and then try to bend it back into its original shape. You might get close, but without special machines, you’ll never get it exactly right.
Proteins are millions of times more complicated than paperclips, and we really don’t even really know how they’re folded to begin with, so right now it would be impossible to unfold one and put it back to where it was before. It’s possible that sometime in the future we might figure it out, but there are a lot of things we need to learn first.
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