Because we don’t know how.
Protein folding is fiendishly complex, something we need a supercomputer to understand the basics. We are only scratching the surface when it comes to predicting how a protein will behave based on its folding. It might be possible to create a custom protein that unfolds a prion, but that is far beyond our current technological capabilities. You might as well as “why can’t we make a drug that kills only cancer cells?”
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