If genetic differences between racial demographics are so small why does testing for clinical drugs need so many representative samples?

168 views

Seems like a contradiction to me. If we are saying the majority of humans are incredibly genetically similar except for some genes that code for pigmentation but also there are reduced clinical efficacy for drugs based on certain races. I can understand outliers like sickle cell anemia but this diversity of sampling is required for every drug.

When they do clinical testing, pharma companies try to pull from different racial groups to ensure their drug works across demographics. If we were that genetically similar then wouldn’t pulling from one group primarily do the job?

Please don’t make this a white supermacist thing. I don’t believe in that stuff. Legitimately just curious.

In: 2

6 Answers

Anonymous 0 Comments

While genetic differences between races is small (in fact, the genetic differences between any two people on Earth of the same biological sex is at most something stupidly small like 0.02%) different races can have different frequencies of alleles (gene variations).

Those same alleles will be found in other races but they will be more of less common in different races. This may change how different medications react in different races statistically but not necessarily individually.

You are viewing 1 out of 6 answers, click here to view all answers.