If genetic differences between racial demographics are so small why does testing for clinical drugs need so many representative samples?

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Seems like a contradiction to me. If we are saying the majority of humans are incredibly genetically similar except for some genes that code for pigmentation but also there are reduced clinical efficacy for drugs based on certain races. I can understand outliers like sickle cell anemia but this diversity of sampling is required for every drug.

When they do clinical testing, pharma companies try to pull from different racial groups to ensure their drug works across demographics. If we were that genetically similar then wouldn’t pulling from one group primarily do the job?

Please don’t make this a white supermacist thing. I don’t believe in that stuff. Legitimately just curious.

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Anonymous 0 Comments

They want to be very very thorough. If even a tiny tiny genetic difference can have an impact on how effective the medicine is, they want to be certain it works. Yes, the genetic differences between humans is relatively minor, mostly surface level, but there are enough tiny quirks that it’s worth being thorough when doing clinical exams.

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