Shouldn’t your body just give you the stop signal and make you not overeat? Then why do people get fat at all?
In: Biology
I was just reading research last night about the GLP-1 agonist drugs (Wegovy, Zepbound). Scientists originally thought the mechanism was simple: release more of the hormone in the gut and the body would respond.
Instead, scientists are learning the reaction actually happens in the brain. The brain gets used to a certain level of these chemicals. Just like with diabetes, tolerance can build up. Once the rubber band is stretched, it’s very difficult to get it to go back to the original setting. We diet, we stretch it more, we give even a little on calories and food craving go way up. These newer drugs quiet that craving.
One incredibly interesting side observation is that craving for other substances (alcohol, drugs) or addictive behaviors can also decrease.
Latest Answers