Knowing how a drug works isn’t required for it to be approved/used. We’ve known for a long time that how we first thought SSRIs worked isn’t how they work. We’ve maybe finally, [this year](https://blogs.sciencemag.org/pipeline/archives/2021/02/19/how-antidepressants-work-at-last) got a real answer. [Here’s](https://blogs.sciencemag.org/pipeline/archives/2021/07/15/a-fifty-year-old-cancer-drug-doesnt-do-what-you-think) a 50 year old cancer drug that doesn’t do what people thought it did. (People knew for a while that we didn’t know how it worked, but we didn’t stop using it)
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