Once you reach the point where you’re getting very large, it starts to be a detriment. The bigger you are, the more your heart has to work to pump blood throughout your body, and while your heart will be stronger than a regular persons, there will be diminishing returns.
Now, unless you’re actually lifting and eating to get large, you’re probably going to be just fine. In that case, you only need to worry about not overworking yourself and/or damaging yourself with improper technique.
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