– Nicotine is a tropane alkaloid, it has the ability to release dopamine in the reward pathways of the brain, why does it not produce consistent euphoria like cocaine; alkaloid or speed: amphetamine?

Question

EDIT – Something I forgot to mention which may add context is that after a period of abstinence I feel a sharp euphoric wave of dopamine which goes away within less than a few minutes and results in dysphoria, even with redosing.

Unlike cocaine, which I’m comparing since both are alkaloids, it seems to build a very unusually fast tolerance and any positive effects dissipate, unlike the latter.

In: 3379

Answer 1

Magical thing called “tolerance”, smoking does produce euphoria but only initially when you start. And it goes quick. The brain is amazing in that it can “turn off” indicating things to you that become “normal”. Also why drug addicts have to take more and more of the drug to get high, eventually going passed how much organs can tolerate and ending in OD.