Imagine skin cells as a bunch of guys holding hands in a random shape.
If you get rid of a few guys, it’s obvious how many you were missing, and you can ask the guy next to the missing spot if he needs a replacement next to him.
But if you get rid of 30 or 50 of them, the remaining guys can’t tell how many are missing, they can only tell a few are missing next to them, but not how far it goes.
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