the difference between the MDMA people take to party and the MDMA used to help treat PTSD.
In: Chemistry
Same drug, in theory. Lots of controlled substances have both medical and non-medical uses. Two meaningful differences, though:
* An active dose in the trials for MDMA-assisted psychotherapy in PTSD is 75-125 mg. An active dose off the street is more variable, one study found a range from zero to 280 mg (not everyone bought real MDMA. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695343/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695343/) and [https://pubmed.ncbi.nlm.nih.gov/21320226/](https://pubmed.ncbi.nlm.nih.gov/21320226/)
* Pharmaceutical-grade MDMA is regulated, shouldn’t have significant impurities, and should have comparable absorption between makers. Street MDMA, as in the study above noted, sometimes isn’t even really MDMA (can be a related chemical or something totally different), and the dose can vary widely.
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