Your body naturally produces many kinds of molecules in order to function. When you regularly use a substance that activates the same spot that is used to receive those natural molecules, your body begins to produce less of its natural supply as it begins to rely on the external supply. Additionally, your body is also becoming more “resistant” to the molecule if you take too much in order to achieve equilibrium, thus increasing tolerance and needing to take more.
Certain molecules (Like GABA) are very important and if you suddenly stop supplying your brain with those molecules, you basically leave your brain empty as it doesn’t produce it naturally like it supposed to anymore, which result in dangerous withdrawals and seizures.
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