Let’s use alcohol as an example, it is central nervous system depressant, it slows your brain down. With constant use the brain compensates in an effort at getting back to normal. This is the origin of drug tolerance or “being able to hold your liquor.”
Over a prolonged period of time the degree of compensation gets to be so great that suddenly stopping its use causes the brain to go into a very over active state that can lead to seizures. The seizures can be so severe that the alcoholic can’t breathe. Withdrawal from alcohol can be fatal.
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