“Biological” in this context means that the active ingredient is produced by a living organism.
Most medicin we can synthesise, that is, we know how to do a string of different chemical reactions, and by the end we have a medication that works.
The active compounds in biologicals are typically large, complex molecules. Rather than try to figure out how to synthesise them, we have genetically engineered another organism, like a bacterium or a fungi, to produce it for us.
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