What are the basics of how a nasal decongestant spray works?
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I’ll cover the sympathomimetic sprays. Your body regulates the width of your blood vessels all the time. If you are in a stressful situation the blood vessels in your muscles will widen, increasing blood flow to allow for better performance. This is mediated by receptors in your blood vessels. But in your respiratory system the opposite is happening, blood vessels are constricted if you are in a stressful situation so that the airflow is maximised. Those nasal decongestant sprays use these receptors, which have a different configuration than the ones in the rest of your body. They activate those receptors, thereby constricting those blood vessels, which leads to reduced swelling. But due to homeostasis they will become less susceptible to this kind of activation after repeated use, and the effect will be reduced also. The balance shifts and then the “standard situation” will be shifted towards swelling. This medication is therefor actually pretty bad. It provides short-term relief at the cost of long-term increased swelling, creating dependence on the drug quickly.
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