Chromosomes are a threadlike structure in human cells which carry our genetic information, or genes. So sex, the way we look, the traits we pick up from parents, how our brain develops and grows, etc. Down syndrome affects the 21st chromosome, giving the affected person a third copy.
The exact reason this third chromosome affects the body and brain so much is still a mystery, despite so much research going into it. But there is a theory called “gene dosage disequilibrium”. It talks about how the third chromosome completely messes up how other genes express themselves, and how the body processes and decodes them. If that makes sense.
Short answer is: We have no idea. We have theories, but the cause for these symptoms is still relatively unknown. [Source](https://www.sciencedaily.com/releases/2014/04/140417133501.htm)
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