The main differences have been covered . . . but here’s a wrinkle.
People with inflammatory bowel diseases (colitis, Crohn’s, etc.) should NEVER take Advil, but Tylenol is okay. Apparently Advil aggravates your condition, despite being an anti-inflammatory.
Source: My gastroenterologist for the past 20 years always ends our visits with a reminder to avoid Advil.
As others have noted, Tylenol (acetaminophen or paracematol) is potentially dangerous for your liver. Most important to note is that it is a common ingredient in other OTC remedies, such as cough syrups, so you are well advised to check labels before taking any OTC remedies in combination as you could exceed recommended dosages.
Advil is an NSAID (non-steroidal anti-inflammatory drug) that’s designed to handle pain and inflammation. Tylenol is also designed to handle pain, but is not an anti-inflammatory.
NSAIDs also cause minor bleeding in the stomach and can increase bleeding from wounds or menses. On the other hand, NSAIDs don’t interact poorly if taken alongside alcohol, whereas Tylenol and alcohol shouldn’t be taken at the same time.
I know you didn’t ask this, but usually the next question is: Which is better or worse for you? And the answer is that’s impossible for anyone here to tell you because it really depends on your medical history, what you’re taking the medication for, and the frequency in which you’re taking the medication itself.
Basically, it’s best to assume that neither are “safe” per se, but both can be taken relatively safely if you follow the directions on the bottle and/or what your physician tells you.
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