In practice, not much. While some people prefer the term pansexual, as it’s more inviting and doesn’t imply only an interest in men and women, the overwhelming majority of people who identify as bisexual don’t reject non-binary people. It’s more that the term “bisexual” was invented in an age before we had a good understanding of non-binary genders. Many bisexual people today define it as “Attracted to both my gender and not-my-gender” instead.
The difference is more or less irrelevant, but it does matter to some people.
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