A flaw in dna coding. There are many factors.
Could be genetics.
Could be congenital (mutation from birth)
Could be a proofreading error from the trna or mrna
Could be environmental (carcinogenic)
But its 99.9999% of the time a coding error, which is any of the above and more.
This puts them in the growth phase and locks them in the growth phase as opposed to the stand by phase.
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