Why are some medications in lower dosage available without prescription but in higher require one? For example ibuprofen.

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You can buy 200mg in every drugstore in hundred packs but for the 600mg you need a prescription. Is it not the same if I take 3 x 200mg or one 600mg? What’s the reason behind this? For me I can’t make sense of it.

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5 Answers

Anonymous 0 Comments

Because ibuprofen exhibits greater anti-inflammatory effects at higher doses, as opposed to just pain relieving effects at OTC doses. If you need to treat inflammation, you need to take more. The downside is that you get worse side effects with higher doses. Stomach ulcers, swelling/water retention, cardiovascular and kidney issues, etc. are all worse at higher doses. NSAIDs like ibuprofen are actually one of the leading causes of prerenal acute kidney injury. Despite being OTC, certain drugs need to be monitored more closely at higher doses.

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