Why are some mutations, like additional limbs or more than 50 chromosomes, are just not possible for humans to have?

Question

Why are some mutations, like additional limbs or more than 50 chromosomes, are just not possible for humans to have?

In: Biology

Answer 1

Your premise is incorrect my dude. Multiple limbs happen, although not always as a mutation. Its called “polymelia”.

And extra or less chromosome disorders occur as well, the most well known likely being Down Syndrome. Disorders with more than the usual number of chromosomes exist as well, but to a less common extent.