Why are SSRI’s and NDRI’s different and how do they affect the brain differently?

Question

Why are SSRI’s and NDRI’s different and how do they affect the brain differently?

In: Biology

Answer 1

Low levels of various chemicals in the brain, including serotonin, norepinephrine, and dopamine, are linked to depression and anxiety. SSRIs block reuptake of serotonin, which allows serotonin to affect the brain longer, while NDRIs block reuptake of norepinephrine and dopamine. One drug may be more effective than the other depending on the patient’s brain chemistry. For instance, someone with low norepinephrine levels might respond better to an NDRI. Since they work on different neurotransmitters, SSRIs and NDRIs also have different side effects, which can also influence treatment choices.