Your brain has hundreds of levers (neurotransmitters) that it uses to tell you what’s going on. When good things happen, it sends moves some levers and you feel good. Drugs work by going in and messing with all the levers, so you feel/think/see things that aren’t appropriate for what is going on around you. This can sometimes damage the levers (or the parts that listen to the status of the lever) because your brain is only supposed to have certain levers on for a certain amount of time.
Damaging those levers (by keeping them on/off too long) can cause long term damage resulting in a world of disorders often including depression and long term paranoia.
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