It seems like the more potent a drug/medication is, the more risks are involved with it, where as drugs with very little risk don’t help nearly as much.
In: Biology
On top of all of your body’s biochemical overlap, which has been addressed in other comments, there’s a selective effect in which drugs get approved for use.
A more potent drug for a more serious condition might be worth enduring the side effects. You’d risk nausea and hair loss to save your life from cancer, but probably not to alleviate a headache.
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