Because the bags of germs that sit in the airports and in the seats next to you on the plane are full of germs and spread them around.
Maintenance crews/cleaners can wipe down hard surfaces and swap filters on a schedule, but the humans sitting next to you are constantly spreading germs with every exhale on your six hour flight.
Add to that the fact that travelers are usually sleep deprived and dehydrated by the dry air in airplanes, and you can see why many people get sick or feel bad after air travel.
Latest Answers