You can go into your mouse options and set your cursor to a crosshair, which naturally clicks at its center. If you do so, you’ll be able to put half your cursor off of every edge – and at the corners you’ll only have a quarter visible.
It’s purely a convention steeped in what’s proven to be useful that the mouse pointer doesn’t actually surround the single pixel to be clicked, but instead minimizes the obscuring effect to a portion of a single quadrant.
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