NSAIDs are notorious for causing gastrointestinal ulceration/bleeds. People with diseases such as crohn’s/ulcerative colitis are already at an increased risk for GI bleeding due to the increased levels of inflammation in the gut walls – adding an NSAID into the mix will increase that risk further.
Apparently NSAIDs can also cause acute flares of IBD, though there’s lots of conflicting snd inconclusive evidence.
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