By the time of Columbus’ first contact with North American peoples, Africa, Europe, and Asia had been in contact for centuries. This meant that all three had shared and adapted to the same diseases. So when European colonization of Africa began in earnest, the indigenous people were much more numerous and resilient.
In contrast, the indigenous population of North America was heavily reduced by disease before colonization really got going. This meant that the colonists faced much less competition from the indigenous people for land and resources, which made colonization much, much easier.
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