Why did the diseases European colonizers brought to the Americas kill off natives in huge numbers but not the other way around?

Question

Why didn’t diseases native to the Americas kill off European colonizers in large numbers?

In: Other

Answer 1

Europeans were harder to make sick because they lived in dense cities under filthy conditions. As a result, they had experienced, or were carrying, many diseases. The native Americans didn’t have a diverse a disease history, living in relative isolation.