Why didn’t diseases native to the Americas kill off European colonizers in large numbers?
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The short answer is that there simply weren’t that many in the new world, and they weren’t widely spread. Remember that Europe had already had several centuries of trade involving Asia, Africa, Scandinavia and many other regions. They had exposure and resistance to the illnesses of many regions by this point, where as the Native American populations had ranges of only several hundred miles at most, and only traded with a limited number of other tribes.
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