A lot of people have misunderstood that question. So i’ll leave out the “why humans do bad at low oxygen pressure and why we shouldn’t do that” bit.
The cabin is not sealed – the air is actually being constantly replenished, under pressure. Think of it like a balloon with a pinprick leak. If you blow into it faster than it is leaking out, then the balloon will stay inflated. This is important because as people breathe in the cabin, oxygen would slowly be replaced with carbon dioxide. You could filter this, spacecraft style, but that’s heavy and expensive. Much easier to just replace the air with fresh (compressed) outside air.
Even if that wasn’t an issue, having a perfectly sealed cabin would spell trouble on flights to different cities. They are at different elevations, and this different ambient pressures. A flight from Los Angeles to Denver would leave the airplane pressurized relative to the outside, creating hazards and a very uncomfortable sudden jump when the doors are opened.
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