Because the air pressure is extremely low at typical cruising altitudes. You’d lose consciousness from lack of oxygen in less than a minute, and would die not long after. That’s why planes have oxygen masks that drop down in case the plane loses pressure. It’s also cold. Like, really cold. Upwards of -60C cold.
As an aside, plane cabins are pressurized, but not to sea level. Usually they’re pressurized to somewhere between 6,000ft – 8,000ft. This is enough to be comfortable for people while also reducing stress on the aircraft from the pressure differential.
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