Why do opioids cause users to be constipated?

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Why do opioids cause users to be constipated?

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4 Answers

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There are opioid receptors in different parts of your body, and your intestines are full of them. In particular they’re called “Mu” opioid receptors (contrasted with Delta and Kappa types) which help to regulate muscle tone in the gut. A lot of anti-diarrhea meds target this, and are in fact non-intoxicating opioids.

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