It’s not that organs get “tired” in the sense like we do after a long day. It’s that they are getting more chronically damaged over time, to the point that they fail. Or that they are at risk of something acute happening such as a heart attack. But really, you die when your body can’t do something that is critical to being alive. If your heart can’t pump blood, you die. If your kidneys fail, you die. If your bones ‘fail’, it’s not going to kill you unless something more important does too
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