why do people with extreme pains that take Opioids don’t feel euphoria as would a normal person feel if they took Opioid ?

Question

I’m learning pharmacology for my exam and found this in my book and its written that its not known why.

In: Biology

Answer 1

Can’t answer your question but it was definitely true for me. I had Stage 4 cancer and was taking just about the Max dosage of oxycodone and, except for the 1st dose where I felt a very slight buzz, I never felt high. Not one bit. And, despite taking it every 2 hours for 4 years, I had no trouble at all reducing the dosage and quitting as the pain went away.