why do people with extreme pains that take Opioids don’t feel euphoria as would a normal person feel if they took Opioid ?

Question

I’m learning pharmacology for my exam and found this in my book and its written that its not known why.

In: Biology

Answer 1

It’s a difficult question because it’s not very precise. I have had opioids for small pain and for big pain. I’m not accustomed to taking opioids and in fact they make me fairly nauseated, but even when being given opioids for a ton of pain, I’ve ben high as a kite for short periods of time. If you have chronic pain and need long term opiod treatment, you’re going to develop a tolerance, but your overall level of pain isn’t going to essentially change whether or not you feel high. That’s going to be based more on your tolerance and probably disposition.